Fatah Moradi; Soran Heidari; Akbar Pejhan
Volume 23, Issue 4 , September and October 2016, , Pages 714-723
Abstract
Background Physical inactivity and obesity have been directly associated with elevated inflammatory markers involving in atherosclerosis, coronary artery disease, and Type II diabetes. The purpose of this study was to survey the effect of 12-week aerobic training on serum levels of interleukin-18 (IL-18) ...
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Background Physical inactivity and obesity have been directly associated with elevated inflammatory markers involving in atherosclerosis, coronary artery disease, and Type II diabetes. The purpose of this study was to survey the effect of 12-week aerobic training on serum levels of interleukin-18 (IL-18) and high-sensitivity C-reactive protein (hsCRP) in sedentary obese men.Methods & Materials In this clinical trial study, 20 sedentary obese men were randomly placed at two groups: aerobic training (n=10, age: 27.8±3.2 y, body fat percentage: 31.7±3.4, BMI: 32.0±3.5 kg/m2) and control (n=11, age: 26.7±2.6 y, body fat percentage 31.4±3.2, BMI: 32.3±2.8 kg/m2). For all subjects, height, weight, body mass index, body fat percentage, maximal oxygen consumption, serum levels of IL-18, and hsCRP (after 12 h fasting) were assessed prior to and after training. Aerobic training was accomplished for 12 weeks (3 sessions per week, intensity 60%-70% of the reserved heart rate, duration of each session 20-40 min). Data were analyzed by SPSS-16 by performing two-way ANOVA with repeated measures test. Statistical significance was accepted at PResults Twelve weeks aerobic training decreased serum levels of IL-18 and hsCRP in sedentary obese men, while no significant changes were observed in the control group.Conclusion It appears that aerobic training can, via influencing on parameters IL-18 and hsCRP, play an important role in reducing incidence of atherosclerosis, coronary artery disease, and Type II diabetics in sedentary obese men.
Mohammad Seyyedahmadi; Akbar Pejhan; Fattah Moradi; Soran Aminiaghaddam
Volume 19, Issue 4 , January and February 2013, , Pages 325-335
Abstract
Background: Adiponectin is the one of adipocytokines, which may be a marker for coronary artery disease and appears to have protective metabolic and anti-inflammatory properties. The purpose of this study was to survey relationships between serum adiponectin levels with insulin resistance, blood pressure, ...
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Background: Adiponectin is the one of adipocytokines, which may be a marker for coronary artery disease and appears to have protective metabolic and anti-inflammatory properties. The purpose of this study was to survey relationships between serum adiponectin levels with insulin resistance, blood pressure, and cardio-respiratory function in sedentary men. Methods and Materials: In semi-experimental study, forty five young men, without experience of regular physical activity during six months ago, were selected. After 12 h fasting (at 8 A.M.), blood samples were collected to determine serum levels of adiponectin, insulin, and glucose. Cardio-respiratory function of subjects was estimated using Balke's treadmill protocol and their blood pressures were measured by sphygmomanometer. Data was analyzed by SPSS 16.0 software and the relationships were calculated by Pearson’s correlation analysis. P value of less than 0.01 was considered statistically significant. Results: Adiponectin levels were negatively correlated to body mass index (r = –0.41, p < 0.002), insulin (r = –0.45, p < 0.009), glucose (r = –0.27, p < 0.007), and HOMA index (r = –0.40, p < 0.002), while positively correlated to maximal oxygen uptake (r = 0.31, p < 0.006). No significant correlations were observed between adiponectin levels and systolic (r = –0.13, p < 0.097) and diastolic blood pressure (r = –0.09, p < 0.117). Conclusions: It appears that in sedentary men, who have lower cardio-respiratory fitness, lower adiponectin levels may be associated with disorder in glycemic, and this promotes probability of diabetes type II and cardiovascular diseases in these subjects. Also, serum concentrations of adiponectin are directly correlated with cardio-respiratory function, but it appears that there is no correlation between adiponectin levels and blood pressure.